Senior Scientist in Sunnyvale, California at Cepheid

Date Posted: 10/6/2018

Job Snapshot

Job Description

Job ID: CEP002093

About Us

At Cepheid, we are passionate about improving healthcare through faster, more accurate diagnostic tests. With our GeneXpert® System, we’ve taken the most sophisticated molecular technology and packaged it into an automated, easy-to-use format that has quickly become the platform of choice worldwide. From the largest laboratories to small physician offices, our game-changing solution delivers critical answers when clinicians and patients need them most. Through strong molecular biology capabilities and ongoing product innovation, we are focused on developing tests for healthcare-associated infections, sexual health, critical infectious disease, virology, and oncology applications. Come join our vision for a better way and help make life better for us all! For more details, visit us at www.cepheid.com or follow us on Twitter (@CepheidNews).


Description

POSITION SUMMARY:

This position is in the Biotechnology group and is primarily a bench level job focusing on real time PCR and RT-PCR assay and product development in an FDA-QSR and ISO9001 compliant organization. Initiates, directs and executes all pre-clinical scientific research and/or development strategies in research and/or development with particular focus on real time PCR assay design and development. The ideal candidate will investigate the feasibility of applying a wide variety of scientific principles and concepts to potential inventions, products and problems and is expected to have a proven track-record of helping to launch in vitro diagnostic products. The candidate will plan and execute laboratory research, demonstrate appropriate technical proficiency, scientific creativity, collaboration with others and independent thought while developing PCR assays for detection of antibiotic resistant bacteria with special focus on Mycobacterium tuberculosis and/or identification of microbial species. The candidate will be expected to participate in development of patent applications and interface with various departments and serve as internal consultant.

  • ESSENTIAL JOB RESPONSIBILITIES:

    • Design and develop real time PCR and RT-PCR assays for the GeneXpert platform for detection of drug resistance in M. tuberculosis and bacterial antimicrobial resistance.
    • Optimize reagent and assay bead formulation for assays in the GeneXpert platform.
    • Perform rigorous analytical studies required for technical feasibility and design and development phases of complex assays prior to validation phase.
    • Formulate algorithms for real time and/ or Tm based identification of antimicrobial resistance markers.
    • Handle clinical samples and perform microbiology work of BSL-1 and BSL-2 organisms, including BSL-2 strains.
    • Help develop strategies for development of complex in vitro diagnostic tests.
    • Help develop and write verification and validation SOPs and technical reports.
    • Maintain detailed experimental records.
    • Apply analytical problem solving skills to reagent and system integration issues to identify critical performance factors.
    • Present data at technical meetings.
    • Allocate time and resources efficiently, effectively prioritize, and continually seek ways to improve individual and corporate efficiency.
    • Be highly goal-oriented and organized and be able to thrive in an atmosphere of shifting demands and priorities.

Job Requirements



Qualifications

    • MINIMUM REQUIREMENTS:

      Education or Experience (in years): 

    • MS with 5 to 8 years of experience, or PhD with 2 to 3 years of experience doing product and process development in an industry setting, preferably at a molecular diagnostics company. Experience in developing molecular diagnostic assay products in microfluidic assay platforms like GeneXpert is highly desirable. Expert level knowledge on real time PCR assay development, primer and probe design and product development is required. Knowledge of developing real time or melt curve based mutation identification and antimicrobial resistance assays. Prior experience in working in GeneXpert platform and knowledge on molecular basis drug resistance in M. tuberculosis will be preferred.

    Knowledge and skills: 

    • Experience working with microorganisms involved in infectious diseases. Experience with Mycobacterium tuberculosis will be a plus.
    • Knowledge of primer and probe design software and data analysis software like Minitab.
    • Knowledge in handling clinical samples such as human sputum or blood and ability to work in a BSL-2 environment. Knowledge of biological and chemical safety.
    • Experienced in interpreting and analyzing large scale experimental data as well as results from clinical trials.
    • Real time PCR or RT-PCR and product development experience. Knowledge of melt technology and applicability to detection of drug resistance will be ideal.
    • Familiarity with drug resistance in bacteria, especially M. tuberculosis.
    • Must possess skills/knowledge in handling clinical specimens and be able to work in a BSL-2 environment.
    • Ability to work in a clean room environment.
    • Excellent documentation and communications skills.
    • Proficiency with standard Microsoft computer programs.
    • Experience with design of experiments methods desirable.

    Physical requirements/abilities: 

    • Ability to work in a research laboratory environment which includes periods of bench-work and working in a bio-safety cabinet


Danaher Corporation Overview

Danaher is a global science & technology innovator committed to helping our customers solve complex challenges and improve quality of life worldwide. Our world class brands are leaders in some of the most demanding and attractive industries, including life sciences, medical diagnostics, dental, environmental and applied solutions. Our globally diverse team of 67,000 associates is united by a common culture and operating system, the Danaher Business System, which serves as our competitive advantage. We generated $18.3B in revenue last year. We are ranked #162 on the Fortune 500 and our stock has outperformed the S&P 500 by more than 1,200% over 20 years.
At Danaher, you can build a career in a way no other company can duplicate. Our brands allow us to offer dynamic careers across multiple industries. We’re innovative, fast-paced, results-oriented, and we win. We need talented people to keep winning. Here you’ll learn how DBS is used to shape strategy, focus execution, align our people, and create value for customers and shareholders. Come join our winning team.