Sr. Staff Scientist, R&D in Framingham, Massachusetts at SCIEX

Date Posted: 8/22/2019

Job Snapshot

Job Description

Job ID: SCI003438

About Us

SCIEX – An operating company within Danaher’s Life Sciences platform

SCIEX helps to improve the world we live in by enabling scientists and laboratory analysts to find answers to the complex analytical challenges they face. Our leadership in LC-MS and CE-MS have made us a trusted partner globally to those who are focused on basic research, drug discovery, food and environmental testing, forensic toxicology, clinical research and diagnostics. With over 40 years of innovation, we continue to redefine what is achievable in routine and complex analysis.

We are seeking smart, team-oriented people who have purpose and are committed to helping us deliver Answers for Science. Knowledge for Life. ™ Our global team, located on every continent, is our greatest strength, bringing diverse perspectives and breakthrough thinking. With the power of the Danaher Business System behind us, it’s our people who have made us the industry leader. Come join our winning team. Visit us at www.sciex.com.

Sciex offers a broad array of comprehensive, competitive benefit programs that add value to associates' and their families' lives. 

Sciex is an equal opportunity employer.  We evaluate qualified applicants without regard to race, color, national origin, religion, gender, age, marital status, disability, veteran status, sexual orientation, gender identity, or any other characteristic protected by law.

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Description

This position’s expectation is to Initiate, direct and execute scientific research focusing on clinical diagnostic & mass spectrometry area. The ideal candidate will Investigate the feasibility of applying a wide variety of scientific principles and concepts to potential inventions, products and problems. Capable of planning, executing and resourcing laboratory research. Candidate shall maintain broad knowledge of state-of-the-art principles and theories in clinical diagnostic and mass spectrometry area. Shall create and protect intellectual properties generated from the research conducted at Sciex in the form of patents and trade-secrets. Shall have good analytical skill for problem solving and be able to work with a team of people with multidisciplinary expertise. Shall be independent thinker and decision maker based on risk assessment. 

Responsibilities
Work closely within the R&D team at Sciex during the product development lifecycle to develop and evaluate specifications for assay related product which has overlap with software and hardware (LC-MS). Develop and optimize sample preparation, LC-MS method development for clinical Dx assays involving single or multiple analytes. Optimization of LC method in various platforms for assays and kits. 
Participate in execution of verification and validation (V&V) of diagnostic assays. Draft requirement, protocol and create record for V&V. Ensure proper record keeping and maintain traceability during the V&V activities. Create and drive project plans for V&V, exploratory research and report regularly to supervisor.  
Compliant with the applicable quality and regulatory requirements. Occasionally support product quality issues as subject matter expert (SME) following CAPA process. 
Provide input on manufacturability and cost analysis during new product development. Build and test initial prototype kit components. 
Maintain 5S in lab, preventative maintenance (PM) plan for key instruments and owner of V&V material inventory. 
Participate, present and lead in group meetings, KAIZENS, Danaher (DBS) trainings and programs, visual management dashboards and project updates. Expected to be a core team member in projects.
Collaborate with SW/HW teams at Sciex to better understand and support the HW/SW product lines. Evaluation of new Sciex or Sciex-partners platforms for Clinical Dx assays 


#LI-SL1.

Job Requirements



Qualifications

A minimum of 8-10 years in a role supporting LC-MS based Clinical Dx R&D and assay development. Experience with of Clinical Dx Assay verification and validation is necessary. Knowledge and experience with 510K clearance process is a plus but not essential.

Proficient in liquid chromatography HW, SW and method development. Must have adequate background in chemistry to understand the surface chemistry, binding and separation properties of different chromatography media and hardware. Up-to-date knowledge on technology landscape on this field is critical. 

Expertise in analytical chemistry including extensive experience with MS/MS method development, optimization, and troubleshooting; preferably using SCIEX equipment.

Familiarly and understanding of CLSI guidelines is critical. Knowledge of ISO and CLEA/CAP guidelines is a plus. 

Excellent communication and interpersonal skills and the ability to work closely with cross-functional teams in a fast-paced environment. Knowledge of scientific project management is necessary.

Advanced skills in Microsoft Office including Excel, PowerPoint, Word, and Visio and project and visual management software.

Education Required

Ph.D. in a relevant scientific discipline (Chemistry, Molecular biology, Analytical Chemistry, Biochemistry, Clinical Chemistry) with 8+ years of industry experience. Knowledge or certificates in Clinical Chemistry is a plus.


Diversity & Inclusion
At Danaher, we are dedicated to building and sustaining a truly diverse and inclusive culture. These are not just words on a page—Diversity and Inclusion is a top priority for the company, and it ties deeply to each of our core values. Danaher Corporation and all Danaher Companies are equal opportunity employers that evaluate applicants without regard to race, color, national origin, religion, sex, age, marital status, disability, veteran status, sexual orientation, gender identity, or other characteristics protected by law.


Danaher Corporation Overview

Danaher is a global science & technology innovator committed to helping our customers solve complex challenges and improve quality of life worldwide. Our world class brands are leaders in some of the most demanding and attractive industries, including life sciences, medical diagnostics, dental, environmental and applied solutions. Our globally diverse team of 71,000 associates is united by a common culture and operating system, the Danaher Business System, which serves as our competitive advantage. We generated $19.9B in revenue last year. We are ranked #162 on the Fortune 500 and our stock has outperformed the S&P 500 by more than 5,200% over 25 years.
At Danaher, you can build a career in a way no other company can duplicate. Our brands allow us to offer dynamic careers across multiple industries. We're innovative, fast-paced, results-oriented, and we win. We need talented people to keep winning. Here you'll learn how DBS is used to shape strategy, focus execution, align our people, and create value for customers and shareholders. Come join our winning team.
Danaher is committed to competitive compensation that typically has key components including base salary, variable annual incentive compensation based on personal and company performance, and long-term incentive.